Isolation of Onosmins A and B, Lipoxygenase Inhibitors from Onosma hispida
نویسندگان
چکیده
منابع مشابه
Epocarbazolins A and B, novel 5-lipoxygenase inhibitors. Taxonomy, fermentation, isolation, structures and biological activities.
New 5-lipoxygenase inhibitors, designated epocarbazolins A and B, were isolated from the culture broth of Streptomyces anulatus T688-8. These compounds showed potent rat 5-lipoxygenase inhibitory activity with weak antibacterial activity. Structural studies revealed that epocarbazolins are new carbazole antibiotics having a novel substitution pattern and an epoxide in the side chain.
متن کاملChem. Pharm. Bull. 53(8) 907—910 (2005)
consists of 85 species, occurring mainly in Iran and westward to Syria, Turkey and Europe. It is represented in Pakistan by 8 species. Onosma hispida WALL. is a perennial herb up to 70 cm tall with a prominent taproot, it is widely distributed in the northern areas of Pakistan. The plant has cooling, laxative, anthalminitic and alexipharmic effects, and is also used to treat diseases of the eye...
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Background and objectives: The cholinergic deficit correlates with the severity of Alzheimer’s disease. The cholinergic function can be improved by AChE inhibitors blocking this key enzyme in the breakdown of acetylcholine. Based on traditional medicine, during two last decades the use of herbal medicinal substances in dementia therapy has been studied. The fruit extract of <em...
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this paper, we describe the production, isolation and structural studies of these new inhibitors. The producing strain was isolated from a soil sample collected in Kisarazu City, Chiba Prefecture, Japan, and taxonomic studies indicated that the strain belonged to the genus Streptomyces. This strain was fermented in 500-ml Erlenmeyer flasks in 100 ml of medium (soluble starch 2.5%, glucose 1 %, ...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 2005
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.53.907